Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S17

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 C   E   Q   L   T   Q   P   E   S       L   T   I   R   P   G   Q   P   L   T
  AJ279380,IGHV3S17*01, 264     TGT GAA CAG CTT ACT CAG CCA GAG TCT ... CTG ACT ATC CGA CCC GGT CAA CCT CTG ACC
                                         H   V                                           T  
  AJ279381,IGHV3S17*02, 48      --- --- --C G-- --- --- --- --- --- ... --- --- --T --C A-- --- --- --- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 I   R   C   Q   V   S   Y   S   V   G   S   W                           T   A
  AJ279380,IGHV3S17*01, 264     ATC CGC TGT CAG GTC TCT TAT TCT GTT GGT AGC TGG ... ... ... ... ... ... ACA GCT

  AJ279381,IGHV3S17*02, 48      --- --T --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   E   G   H   A   L   E   W   I   S   M   I   N   T   G   G
  AJ279380,IGHV3S17*01, 264     TGG ATA AGA CAA CCT GAA GGA CAC GCA CTG GAA TGG ATT AGC ATG ATA AAT ACT GGG GGC

  AJ279381,IGHV3S17*02, 48      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 K                   H   Q   K   D   S   L   S       S   K   F   S   L   T   L
  AJ279380,IGHV3S17*01, 264     AAA ... ... ... ... CAC CAG AAA GAC TCT CTT AGT ... AGT AAA TTC AGT CTC ACC CTT

  AJ279381,IGHV3S17*02, 48      --- ... ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---


                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   V   A   S   K   T   I   T   L   Q   G   Q   N   M   Q   P   G   D   S   A
  AJ279380,IGHV3S17*01, 264     GAC GTG GCC AGT AAA ACA ATT ACT TTG CAA GGG CAG AAC ATG CAG CCT GGA GAC TCA GCT

  AJ279381,IGHV3S17*02, 48      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   G
  AJ279380,IGHV3S17*01, 264     GTG TAT TAC TGT GCC GGT     #c
                                                     V
  AJ279381,IGHV3S17*02, 48      --- --- --- --- --- -T-     #c
#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc